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. 2022 Jun 20;204:105367. doi: 10.1016/j.antiviral.2022.105367

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Fig. 4 — Novel compounds with anti-NAK activity suppress SARS-CoV-2 infection.

(A) Chemical structures of RMC-76, RMC-242, SCG-GAK-1, and STK16-IN-1. (B) Dose response of WT SARS-CoV-2 infection to the indicated compounds in Vero E6 cells infected with USA-WA1/2020 strain and in Calu-3 cells infected with rSARS-CoV-2/Nluc (MOIs = 0.05) (black) measured via plaque and Nluc assays at 24 hpi, respectively. Dose response of cellular viability to the indicated compounds measured via alamarBlue assays are shown in blue. (C) Heat maps of the EC₅₀ and CC₅₀ values of the inhibitors color-coded based on the antiviral activity and cell viability measured in the indicated cell lines. Selectivity indices (SI, CC₅₀ to EC₅₀ ratios) greater than 5 are depicted in yellow. Data in all panels are representative of two or more independent experiments. Individual experiments had three or greater biological replicates. Shown are means ± SD.