Table 1.
Chicken anti-IBV VN antibody response and protection from challenge with virulent IBV
| Group | Immunizationa | Dose (g) | Route | Serum VN titerb |
No. protected/no. challenged | |
|---|---|---|---|---|---|---|
| Second vaccination | Third vaccination | |||||
| 1 | Transgenic potato tubers | 2.5 | Oral | 1:84.4 | 1:2455 | 4/6 |
| 2 | Transgenic potato tubers | 5 | Oral | 1:129.9 | 1:3447 | 4/6 |
| 3 | Wild type tubers | 5 | Oral | 0 | 0 | 0/6 |
| 4 | Transgenic potato tuber extracts | 2.5 | i.m.c | 1:12.6 | 1:3654 | 5/6 |
| 5 | Transgenic potato tuber extracts | 5 | i.m.c | 1:133.4 | 1:5754 | 5/6 |
| 6 | Live attenuated vaccine | One dose | i.n.c | 1:13.0 | 1:3108 | 6/6 |
| 7 | Buffer | 5 | Oral | 0 | 0 | 0/6 |
a
Each group consisted of six chickens which were immunized three times with transgenic potato tubers.
b
VN titer was geometry mean titer.
c
i.m., intramuscular; i.n., intranasal.