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. 2022 Jun 16;150(2):312–324. doi: 10.1016/j.jaci.2022.05.019

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Fig 3 — A, Schematic of the experimental approach. B, PCA of the total immune compartment on the basis of all extracted immune features grouped by comorbidity. C, Comorbidity effect size (ES) filter. Dot plot displaying the ES of every immune feature calculated for the indicated comorbidity versus without the indicated comorbidity. Each dot represents 1 immunologic feature, colored for the affected immune compartment. An ES of 0.2 represents the filter cutoff for further in-depth analysis of immune features. D, COVID-19 severity ES filter. Dot plot displaying the ES of every immune feature calculated for severe versus mild COVID-19. Each dot represents 1 immunologic feature, colored for the affected immune compartment. An ES of 0.3 represents the filter cutoff for further in-depth analysis of immune features. E, PCA of the total immune compartment based on all severe COVID-19–associated (ES severe vs mild COVID-19 > 0.3) immune features grouped by comorbidity.