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. 2022 Jun 16;150(2):312–324. doi: 10.1016/j.jaci.2022.05.019

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© 2022 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 5 — A and B, Dot plot displaying the effect size (ES) of severe versus mild COVID-19 (x-axis) against the ES of the indicated comorbidity versus without the indicated comorbidity (y-axis). Each dot represents 1 immunologic feature, colored for the affected immune compartment. The black box highlights immune features for further in-depth analysis. C-F, The median expression and 25th and 75th percentiles of the indicated parameters in the indicated FlowSOM-generated immune cell clusters. Comparison of patients with HD, patients with no HD, and healthy controls (C-E), and patients with an LAD, patients with no LAD, and healthy controls (F). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; Mann-Whitney test and Benjamini-Hochberg correction.