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. 2022 Jun 16;185(16):2952–2960.e10. doi: 10.1016/j.cell.2022.06.023

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Mutation distribution in VOC S proteins and SPR for VOC RBD binding to hACE2 and VOC pseudovirus entry assay

(A) Schematic diagram for mutation distribution in the S proteins from the five VOCs, including the four Omicron sub-variants (BA.1, BA.1.1, BA.2, and BA.3). The mutations unique to BA.1.1, BA.2, or BA.3 are indicated in blue. The mutations unique to BA.2 and BA.3 are indicated in green. The mutations present in BA.1 and BA.1.1 but absent in BA.2 and BA.3 are shown with dashed lines.

(B) Donut chart for the global composition of Omicron sub-variants (data were collected from GISAID on April 25^th, 2022).

(C) The SPR curves for the VOC RBDs binding to hACE2.

(D) Pseudovirus entry assay for the five VOCs, including the four Omicron sub-variants (BA.1, BA.1.1, BA.2, and BA.3). The error bars indicate the standard deviations (SD) for three or four independent experiments.

See also Figure S1.