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Amino acids at RBD sites in each control lineage used. 1Omicron (BA.x) is included for comparison, but had not yet been identified during initial validation of the assay. 2Omicron has the N501Y change, but also has additional mutations within the probe site (G496S and Q498R in BA.1, Q498R in other subvariants) that reduce fluorescence amplitude.
| Amino acid target | ||||
|---|---|---|---|---|
| Lineage | 417 | 452 | 484 | 501 |
| D614G | K | L | E | N |
| Beta | N | L | K | Y |
| Gamma | T | L | K | Y |
| Kappa | K | R | Q | N |
| BA.1/BA.21 | N | L | K | Y2 |
| BA.4/BA.51 | N | R | K | Y2 |
