Table 1.

Demographic Characteristics (Safety Population).

Characteristics	Low Dose N = 51	Medium Dose N = 51	High Dose N = 51	Overall N = 153
Age at time of informed consent (years)
N	51	51	51	153
Mean (SD)	33.7 (8.89)	35.5 (9.53)	31.3 (8.52)	33.5 (9.10)
Median	31.0	33.0	29.0	32.0
Min, max	21, 53	21, 55	18, 54	18, 55
Sex, n (%)
Male	27 (52.9)	34 (66.7)	22 (43.1)	83 (54.2)
Female	24 (47.1)	17 (33.3)	29 (56.9)	70 (45.8)
Diverse	0	0	0	0
Childbearing potential
N	51	51	51	153
Yes	23 (45.1)	16 (31.4)	28 (54.9)	67 (43.8)
No	1 (2.0)	1 (2.0)	1 (2.0)	3 (2.0)
Reason for no childbearing potential
Surgically sterile	1 (2.0)	0	0	1 (0.7)
Postmenopausal	0	1 (2.0)	1 (2.0)	2 (1.3)
Ethnicity, n (%)
White	46 (90.2)	51 (100.0)	46 (90.2)	143 (93.5)
Black	0	0	0	0
Asian	1 (2.0)	0	0	1 (0.7)
Mixed	0	0	4 (7.8)	4 (2.6)
LatinA	1 (2.0)	0	0	1 (0.7)
Latin AmericanA	2 (3.9)	0	0	2 (1.3)
LatinoA	1 (2.0)	0	0	1 (0.7)
White EuropeanB	0	0	1 (2.0)	1 (0.7)
Body Mass Index (BMI) at screening (kg/m2)
N	51	51	51	153
Mean (SD)	24.87 (2.962)	25.06 (2.238)	24.5 (3.085)	24.81 (2.778)
Median	24.7	24.9	24.5	24.8
Min, Max	19.6, 29.9	20.2, 29.2	18.1, 29.8	18.1, 29.9
COVID-19 test result at screening
Positive	0	0	0	0
Negative	51 (100.0)	51 (100.0)	51 (100.0)	153 (100.0)
Hepatitis-BsAg test result at screening
Positive	0	0	0	0
Negative	51 (100.0)	51 (100.0)	51 (100.0)	153 (100.0)
HCV test result at screening
Positive	0	0	0	0
Negative	51 (100.0)	51 (100.0)	51 (100.0)	153 (100.0)
HIV test result at screening
Positive	0	0	0	0
Negative	51 (100.0)	51 (100.0)	51 (100.0)	153 (100.0)

Max=maximum; Min=minimum; SD=standard deviation

A: Latin/Latino American / Latino: confirmed all 4 participants as Latin American with Mexico as country of birth.

B: White European.