TABLE 3.
Mean metabolite ratios and their standard deviations in the TBI and control groups in ROIs showing metabolic differences between groups
| Metabolite | ROI | TBI group |
Controls |
Mean difference 95% CI | t | df | P value | ||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Number (%) voxels | Mean (SD) | Number (%) voxels | ||||||
|
| |||||||||
| CHO/CR | R posterior cingulate | 0.208 (0.023) | 24 (91.87) | 0.176 (0.023) | 20 (82.06) | 0.032 (0.011, 0.053) | 3.192 | 19 | .005 |
| Splenium of corpus callosum | 0.290 (0.027) | 85 (76.26) | 0.668 (0.092) | 84 (79.74) | 0.032 (0.004, 0.061) | 2.355 | 19 | .029 | |
| L posterior cingulate | 0.226 (0.032) | 15 (80.88) | 0.193 (0.036) | 14 (79.97) | 0.032 (0.000, 0.064) | 2.105 | 19 | .050 | |
| MI/CR | R fusiform gyrus | 0.659 (0.077) | 84 (63.75) | 0.560 (0.042) | 72 (58.32) | 0.099 (0.041, 0.156) | 3.585 | 19 | .002 |
| R pallidum | 0.555 (0.165) | 8 (50.98) | 0.322 (0.101) | 8 (50.42) | 0.233 (0.093, 0.372) | 3.528 | 17b | .003 | |
| L sagittal striatum | 0.703 (0.084) | 21 (67.94) | 0.613 (0.049) | 21 (77.23) | 0.089 (0.025, 0.154) | 2.904 | 18c | .009 | |
| R putamen | 0.514 (0.088) | 31 (53.49) | 0.399 (0.105) | 35 (64.52) | 0.115 (0.027, 0.203) | 2.733 | 19 | .013 | |
| R hippocampus | 0.804 (0.158) | 32 (62.15) | 0.673 (0.044) | 30 (60.78) | 0.131 (0.022, 0.239) | 2.636 | 11.656a | .022 | |
| L lingual gyrus | 0.621 (0.077) | 102 (79.58) | 0.543 (0.058) | 112 (88.51) | 0.078 (0.152, 0.141) | 2.600 | 19 | .018 | |
| Splenium of corpus callosum | 0.796 (0.146) | 85 (76.26) | 0.668 (0.092) | 84 (79.74) | 0.128 (0.015, 0.241) | 2.375 | 19 | .028 | |
| Body of corpus callosum | 0.724 (0.147) | 69 (71.86) | 0.615 (0.039) | 75 (83.22) | 0.109 (0.008, 0.210) | 2.370 | 11.516a | .036 | |
| R sagittal striatum | 0.802 (0.142) | 22 (78.40) | 0.690 (0.066) | 20 (77.10) | 0.112 (0.010, 0.214) | 2.347 | 14.451a | .034 | |
| L posterior corona radiata | 0.729 (0.153) | 18 (85.86) | 0.603 (0.092) | 19 (92.32) | 0.126 (0.009, 0.243) | 2.258 | 19 | .036 | |
| L anterior cingulate | 0.754 (0.136) | 20 (26.13) | 0.622 (0.127) | 27 (39.43) | 0.132 (0.009, 0.256) | 2.247 | 18c | .037 | |
| R posterior cingulate | 0.638 (0.070) | 24 (91.87) | 0.581 (0.047) | 20 (82.06) | 0.057 (0.002, 0.112) | 2.175 | 19 | .042 | |
| L anterior limb of internal capsule | 0.634 (0.149) | 55 (74.06) | 0.524 (0.078) | 54 (77.39) | 0.110 (0.001, 0.219) | 2.153 | 15.372a | .048 | |
| NAA/CR | R putamen | 0.948 (0.149) | 31 (53.49) | 1.081 (0.095) | 35 (64.52) | −0.133 (−0.249, −0.018) | −2.416 | 19 | .026 |
| R anterior limb of internal capsule | 1.104 (0.181) | 53 (72.44) | 1.248 (0.090) | 57 (82.61) | −0.144 (−0.276, −0.013) | −2.338 | 14.975a | .034 | |
Note: T-values and P values are from independent-samples t-tests comparing the metabolite ratio means. TBI group, n = 11; control group, n = 10.
Abbreviations: CHO/CR, choline/creatine; CI, confidence interval; L, left; MI/CR, myo-inositol/creatine; NAA/CR, N-acetylaspartate/creatine; R, right; ROI, region of interest; TBI, traumatic brain injury.
a
df adjusted for unequal variances.
b
Missing data from two control participants.
c
Missing data from one control participants.