TABLE 5.
Significant correlations between metabolite ratios and self-reported symptoms in the TBI group in regions showing metabolic differences
| Metabolite | ROI | rs | P |
|---|---|---|---|
|
| |||
| Associations with pain interference | |||
| MI/CR | R posterior cingulate | 0.684 | .020 |
| R hippocampus | 0.676 | .022 | |
| Associations with fatigue severity | |||
| MI/CR | R sagittal stratum | 0.789 | .004 |
| R posterior cingulate | 0.741 | .009 | |
| Body of corpus callosum | 0.719 | .013 | |
| L anterior limb of internal capsule | 0.673 | .023 | |
| Associations with HADS anxiety | |||
| CHO/CR | Splenium of corpus callosum | 0.731 | .011 |
| R posterior cingulate | 0.663 | .026 | |
| Associations with HADS depression | |||
| MI/CR | R putamen | 0.729 | .011 |
| R posterior cingulate | 0.617 | .043 | |
Abbreviations: CHO/CR, choline/creatine; HADS, Hospital Anxiety and Depression Scale; MI/CR, myo-inositol/creatine; ROI, region of interest; TBI, traumatic brain injury.