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. 2022 Jun 17;15:3161–3171. doi: 10.2147/IDR.S367588

Table 2.

Antimicrobial Spectrum Evaluation Percentage of Carbapenem-Resistant Klebsiella pneumoniae Isolates Resistance to Various Antibiotics

Antimicrobial Agents CRKP Isolates (n=56) CSKP Isolates (n=47) P-value
MIC50 MIC90 R% MIC50 MIC90 R%
CTX 256 >256 100 48 >128 74.5 <0.01
CAZ >256 >256 100 8 128 55.3 <0.01
FEP 128 >256 100 8 16 61.7 <0.01
CT 0.25 0.5 1.8 0.5 0.5 0 0.362
TGC 1 4 12.5 1 2 8.5 0.519
IMP 16 >32 89.3 ≤0.25 0.375 2.1 <0.01
ETP >16 >16 100 ≤0.25 ≤0.25 2.1 <0.01
MEM 16 >16 94.6 ≤0.25 0.25 0 <0.01
CIP 2 128 57.1 1 64 42.6 0.134
FOS 512 >512 92.9 >512 >512 97.9 0.24
SXT 2/38 16/304 48.2 >16 >16 59.6 0.254
PTZ 512 >512 94.6 4 12 8.5 <0.01
AMK 4 >256 48.2 2 4 6.4 <0.01
GEN 128 >256 60.7 ≤1 128 38.3 0.023
ATM >128 >128 96.4 12 128 55.3 <0.01

Note: P values less than 0.05 are bolded.

Abbreviations: CTX, cefotaxime; CAZ, ceftazidime; FEP, cefepime; CT, colistin; TGC, tigecycline; IMP, imipenem; ETP, ertapenem; MEM, meropenem; CIP, ciprofloxacin; FOS, fosfomycin; SXT, trimethoprim-sulfamethoxazole; PTZ, piperacillin-tazobactam; AMK, amikacin; GEN, gentamicin; ATM, aztreonam.