Table 1.

The Main Protein Partners of Podoplanin

Ligands	Binding sites with Podoplanin	Functions	References
CLEC-2	Extracellular Domain	Platelet activation Thrombosis Blood vascular integrity Lymphangiogenesis Immune response Cancer invasion and metastasis	[2,4,16–18]
CCL21	Extracellular Domain	Immune response Development of nature Treg cells Tumor immune escape	[2,19,20]
Galectin-8	Extracellular Domain	Lymphangiogenesis	[21]
CD9	Transmembrane Domain	Inhibition of podoplanin-CELC-2 interaction	[22]
CD44	Transmembrane Domain	Modulation of cell migration	[23]
ERM	Cytoplasmic Tail	Embryonic development Immune response Cancer invasion and metastasis Epithelial-mesenchymal transition	[13–15]