Table 1.
Results of Preliminary Docking with NTD of N protein.
Results of Preliminary Docking with NTD of N protein | |||
---|---|---|---|
S.no | Compound name | Estimated Binding Affinity Range [in nm] | Current use of the Ligand |
1. | Dfo | 24–2408 | An amino derivative of Dfo, Deferoxamine is used for treatment of iron overdose and aluminum toxicity in people on dialysis. It is being explored as a potential modality for Hypoxia, Diabetes Mellitus, Intracranial Aneurysm and Diabetic Foot Ulcer (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.). |
2. | Faslodex | 430–42753 | Used to treat metastatic breast cancer in postmenopausal women. Its efficacy against Lung Neoplasms, Colorectal Neoplasms, Glandular and Epithelial Ovarian Neoplasms are being determined through clinical trials (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.). |
3. | Benzonatate, (Tessalon) | 1002–99553 | Tessalon is used to alleviate the symptoms of cough and hiccups (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.). |
4. | Iloperidone, (Fanapt) | 3505–348292 | Fanapt is an atypical antipsychotic for the treatment of schizophrenia (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.). |
5. | Phenyltoloxamine | 3318–329652 | An antihistamine with sedative and analgesic effects. Used as a cough suppressant and is available in combination with other drugs like paracetamol (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.). |