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. 2022 Jun 21;127:103188. doi: 10.1016/j.pce.2022.103188

Table 1.

Results of Preliminary Docking with NTD of N protein.

Results of Preliminary Docking with NTD of N protein
S.no Compound name Estimated Binding Affinity Range [in nm] Current use of the Ligand
1. Dfo 24–2408 An amino derivative of Dfo, Deferoxamine is used for treatment of iron overdose and aluminum toxicity in people on dialysis. It is being explored as a potential modality for Hypoxia, Diabetes Mellitus, Intracranial Aneurysm and Diabetic Foot Ulcer (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.).
2. Faslodex 430–42753 Used to treat metastatic breast cancer in postmenopausal women. Its efficacy against Lung Neoplasms, Colorectal Neoplasms, Glandular and Epithelial Ovarian Neoplasms are being determined through clinical trials (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.).
3. Benzonatate, (Tessalon) 1002–99553 Tessalon is used to alleviate the symptoms of cough and hiccups (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.).
4. Iloperidone, (Fanapt) 3505–348292 Fanapt is an atypical antipsychotic for the treatment of schizophrenia (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.).
5. Phenyltoloxamine 3318–329652 An antihistamine with sedative and analgesic effects. Used as a cough suppressant and is available in combination with other drugs like paracetamol (Irwin et al., 2012; Sterling and Irwin, 2015; Irwin, & Sterling, n.d.).