Table 3.
Summary of the Reported Cases of Endocrinopathy After SARS-CoV-2 Vaccination
| Endocrine organ (ref) | Age and sex (M/F) | Product | Type of vaccines | Onset after vaccination | Endocrinopathy/symptoms | Clinical course |
|---|---|---|---|---|---|---|
| Pituitary | 48 y, F (current case) | BNT162b2 (Pfizer-BioNTech) | mRNA | 2 d | Hypophysitis/polyuria, polydipsia, headache | Partial improvement |
| Pituitary12 | 51 y, M | Spikevax (Moderna) | mRNA | 2-3 d | Hypopituitarism/nausea, vomiting, abdominal pain | Spontaneous improvement |
| Pituitary21 | 37 y, F | Vaxzevria (AstraZeneca) | Adenovirus vector | 5 d | Apoplexy/sudden headache, hemorrhagic adenoma | No pituitary hormone abnormalities, spontaneous recovery in 2-3 wk |
| Adrenal20 | 47 y, M | Vaxzevria (AstraZeneca) | Adenovirus vector | 1 d | Adrenal insufficiency/neurologic symptoms, thrombocytopenia | N/A |
| Thyroid17 | 57 y, F | BNT162b2 (Pfizer-BioNTech) | mRNA | 1 d | Hyperthyroidism/fever, thyrotoxicosis | Symptoms started after the first dose and then worsened after the second dose |
| Thyroid10 | 26 y, F | Vaxzevria (AstraZeneca) | Adenovirus vector | 2 d | Hyperthyroidism/neck pain, palpitation | Full recovery at 6 wk |
| Thyroid11 | 35 y, F | CoronaVac (Sinovac) | Inactivated | 4 d | Hyperthyroidism/fever, neck pain, fatigue | Developed after the second dose, euthyroid after 1 mo of steroid |
| Thyroid11 | 34 y, F | CoronaVac (Sinovac) | Inactivated | 4 d | Fever, neck pain, fatigue | SARS-CoV-2 infection prior to vaccination, on steroid 1 mo, symptoms persisted |
| Thyroid13 | 42 y, F | BNT162b2 (Pfizer-BioNTech) | mRNA | 4 d | Fever, neck pain, palpitation | Symptoms started after the first dose and then worsened after the second dose |
| Thyroid18 | 51 y, F | BNT162b2 (Pfizer-BioNTech) | mRNA | 4 d | Fever, neck pain, nausea | Methimazole and steroid were administered, euthyroid at 2 mo |
| Thyroid22 | 42 y, F | BNT162b2 (Pfizer-BioNTech) | mRNA | 5 d | Hyperthyroidism/sore throat, palpitation | Symptoms started after the first dose |
| Thyroid19 | 34 y, F | Covaxin (Bharat Biotech) | Inactivated | 5 d | Hyperthyroidism/fever, neck pain, palpitation | Steroid administered, euthyroid at 7 wk |
| Thyroid21 | 42 y, F | Spikevax (Moderna) | mRNA | 5 d | Ear pain, dysphagia | Symptoms resolved but hypothyroidism at 2 mo |
| Thyroid10 | 49 y, F | Spikevax (Moderna) | mRNA | 1 wk | Sore throat, headache | Still on prednisone 1 mo after |
| Thyroid11 | 37 y, F | CoronaVac (Sinovac) | Inactivated | 1 wk | Neck pain | Developed after the second dose, spontaneous recovery at 2 mo |
| Thyroid16 | 75 y, M | Vaxzevria (AstraZeneca) | Adenovirus vector | 2 wk | Hyperthyroidism/neck pain, palpitation | Symptoms persisted at 3 mo |
| Thyroid14 | Middle age, F | BNT162b2 (Pfizer-BioNTech) | mRNA | 2 wk | Neck pain | Euthyroid at 3 mo |
| Thyroid15 | 55 y, F | Vaxzevria (AstraZeneca) | Adenovirus vector | 3 wk | Headache, sore throat, palpitation | Subacute thyroiditis, hypothyroidism persisted at 4 mo |
| Thyroid18 | 39 y, F | Vaxzevria (AstraZeneca) | Adenovirus vector | 3 wk | None | Euthyroid at 2 mo |
Abbreviations: F = female; M = male; mRNA = messenger ribonucleic acid; N/A = not available.