Table 2.
Evolutionary distances and binding affinities of SARS-CoV-2 spike proteins with ACE2.
| Measure | Wild type | Alpha (B.1.1.7) | Beta (B.1.351) | Gamma (P.1) | Delta (B.1.617.2) | Omicron BA.1 (B.1.1.529/BA.1) | Omicron BA.2 (B.1.1.529/BA.2) |
|---|---|---|---|---|---|---|---|
| Evolutionary distance | 0 | 0.00420 | 0.00446 | 0.01077 | 0.01209 | 0.01426 | 0.02600 |
| ZDOCK scores of the most stable complexes | 216.076 | 253.965 | 264.905 | 282.820 | 454.240 | 509.856 | 615.442 |
| ZDOCK scores of the most stable clusters (mean ± SD) | 219.633 ± 50.513 (n = 10) | 247.478 (n = 1) | 260.243 (n = 1) | 270.947 (n = 1) | 428.721 (n = 1) | 417.824 ± 4.936 (n = 5) | 595.340 ± 4.736 (n = 3) |