REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Alexaflour-647	Novus Biologicals	ab269823; RRID:AB_2892763
CR3022	Sigma-Aldrich	ZHU1077; RRID:AB_2848080
Bacterial and virus strains
EHC-83E	Mid-turbinate nasal swab	SARS-CoV-2/human/USA/GA-EHC-083E/2020
B.1.617.2	Mid-turbinate nasal swab	hCoV-19/USA/PHC658/2021
B.1.351	Dr. Andy Pekosz (John Hopkins University, Baltimore, MD)	hCoV-19/South Africa/KRISP-K005325/2020
B.1.1.529	Mid-turbinate nasal swab	hCoV19/EHC_C19_2811C
Chemicals, peptides, and recombinant proteins
Methylcellulose	Sigma-Aldrich	Cat. #: M0512-250G
Critical commercial assays
Bright-Glo Luciferase Assay System	Promega	Cat# E2610
Opti-MEM	Life Technologies	Cat# 31,985,062
Experimental models: Cell lines
HEK 293T/17 cells	American Type Culture Collection	Cat# CRL-11268
293T/ACE2 cell	Drs. Michael Farzan and Huihui Mu	N/A
VeroE6 C1008 cells	ATCC	Cat# CRL-1586, RRID:CVCL_0574
Recombinant DNA
VRC5601: pHR' CMV Luc	Vaccine Research Center, NIH	N/A
VRC5602: pCMV ΔR8.2	Vaccine Research Center, NIH	N/A
VRC9260: TMPRSS2	Vaccine Research Center, NIH	N/A
VRC7480	Vaccine Research Center, NIH	N/A
VRC7480.D614G	This paper	N/A
VRC7480.Omicron.BA.1	This paper	N/A
VRC7480.Omicron.BA.2	Genscript	N/A
VRC7480.Omicron.BA.3	Genscript	N/A
VRC7480.Omicron.BA.2.12.1	This paper	N/A
VRC7480.Omicron.BA.4/BA.5	Genscript	N/A
Software and algorithms
GraphPad Prism 9.2.0	San Diego, CA	N/A
Viridot Program	Katzelnick et al.14	https://github.com/leahkatzelnick/Viridot
R Version 4.1.3	R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/	N/A
SAS Version 9.4	SAS Institute Inc., Cary NC, USA	N/A