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. 2022 Jun 16;1:100002. doi: 10.1016/j.vesic.2022.100002

Fig. 2.

Fig. 2

Biodistribution of nebulized labeled nanoparticles in the lung. (A) Schematic of mRNA and protein loading, nebulization administration, and ex vivo histology. Created with BioRender.com. (B) Representative ex vivo images of mouse lungs after mRNA and protein loaded Lung-Exo, HEK-Exo, and Lipo nebulization. (C) Quantification of the integrated density of GFP and RFP fluorescence in ex vivo mouse lungs; n = 1 per group. (D) Quantification of the integrated density of GFP and RFP fluorescence in ex vivo mouse lungs 24 h after nebulization; n = 3 per group. (E) Immunoblots of GFP and RFP in mouse lung lysate. (F) Quantification of immunoblots normalized to β-actin; n = 3 per group.