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. 2022 Jun 17;15:3111–3133. doi: 10.2147/IDR.S360973

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© 2022 Odiba et al.

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A depiction of the binding poses of two different azole drugs in the CYP51 drug-binding pocket. (A) shows the interaction of posaconazole (yellow) with different active site residues (blue) and prosthetic heme group (brown) of the C. albicans CYP51. (B) shows the interaction of fluconazole (green) with different active site residues (blue) and prosthetic heme group (brown) of the S. cerevisiae CYP51.

Notes: A similar study by Zhang et al serves as additional evidence/support for our original analysis.⁷²