Table 1.
Characteristics of included studies.
| Study Year | Treatment | Control | Number (T/C) | Duration | Results report |
|---|---|---|---|---|---|
| Bao et al. 2002 [17] | Salvia miltiorrhiza injection (6–10 ml ivgtt qd) + conventional steroid treatment | Conventional steroid treatment | 24/20 | 2 weeks | Scr, BUN, 24 h UPE, ALB |
| Huang 2009 [18] | Salvia miltiorrhiza injection (20 ml ivgtt qd) + conventional treatment | Conventional treatment | 46/46 | 2 weeks | Effective rate |
| Wang et al. 2015 [19] | Salvia miltiorrhiza Injection (1 ml ivgtt qd) + Huang qi injection (2.5 ml) + conventional treatment | Conventional treatment | 30/29 | 2 months | Scr, BUN, Ccr |
| Wang and Zhao [20] | Salvia miltiorrhiza injection (400 mg ivgtt qd) + conventional treatment | Conventional treatment | 53/45 | 35 days | Effective rate, SCr |
| Wang et al. 2008 [21] | Salvianolate injection (200 mg ivgtt qd) + alprostadil Injection (30 μg ivgtt qd) + reduced glutathione injection (2.4 g ivgtt qd) conventional treatment | Conventional treatment | 42/42 | 7 days | BUN SCr, BUN, GFR |
| Liu 2017 [22] | Salvianolate injection (200 mg ivgtt qd) + conventional treatment | Conventional treatment | 30/30 | 2 weeks | CySC, adverse effect |
| Fu et al. 2012 [23] | Salvianolate Injection (200 mg ivgtt qd) + alprostadil Injection (20 μg ivgtt qd) + reduced glutathione Injection (2.4 g ivgtt qd) + conventional treatment | Conventional treatment | 15/15 | 12 to 64 months | Effect time to initiation of |
| Liu 2015 [24] | Salvianolate injection (100 mg ivgtt qd) + conventional treatment | Conventional treatment | 16/16 | 2 weeks | Dialysis, adverse effect of SCr, BUN |
| Hu et al. 2011 [25] | Salvianolate injection (200 mg ivgtt qd) + conventional treatment | Conventional treatment | 27/27 | 4 weeks | SCr, 24 h UPE |
| Sun and Luo 2012 [26] | Salvianolate injection (200 mg ivgtt qd) + conventional treatment | Conventional treatment | 40/38 | 2 weeks | Effective rate, SCr |
| Xiong et al. 2007 [27] | Salvia miltiorrhiza injection (80 mg ivgtt qd) + TCM decoction ((Rhubarb 20 g, calcined keel 20 g, calcined oyster 20 g, dandelion 20 g, Ligusticum chuanxiong 20 g) 300 ml retention enema for 1-2 h, qd) + conventional treatment | Conventional treatment | 40/40 | 30 days | BUN, Ccr, adverse effect effective rate, SCr |
| Wang et al. 2007 [28] | Salvia miltiorrhiza injection (800 mg ivgtt qd) + conventional treatment | Xueshuantong Injection (450 mg ivgtt qd) + conventional treatment | 24/23 | 15 days | BUN, GFR, Hb, ALB, adverse effect effective rate |
| Xu et al. 2011 [29] | Salvia miltiorrhiza injection (20 ml ivgtt qd) + Huang qi injection (40 g ivgtt qd) + conventional treatment | Conventional treatment | 39/36 | 2 weeks | Effective rate, SCr |
| Guohua et al. 2009 [30] | Salvia miltiorrhiza tablet (4 pills tid p.o.) + irbesartan (150 mg qd p.o.) + conventional treatment | Irbesartan (150 mg qd pop.o.) + conventional treatment | 32/31 | 6 months | BUN, CysC, Hb, ALB, CRP effective rate, SCr |
| Wang 2012 [31] | Salvia miltiorrhiza injection (800 mg ivgtt qd) + Valsartan (80 mg p. o. qd) + conventional treatment | Valsartan (80 mg p.o. qd) + conventional treatment | 30/30 | 4 weeks | BUN, 24 h UPE, TC SCr, 24 h UPE, TC |
| Xiang and Mo 2011 [32] | Sodium Tanshinone II A sulfonate injection (40 mg ivgtt qd) + TCM decoction ((Rhubarb 10 g, Calcined oyster 20 g, Dandelion 30 g) 400 ml retention enema for 20–30 m, bid) + conventional treatment | TCM decoction [(Rhubarb 10 g, Calcined oyster 20 g, Dandelion 30 g) 400 ml retention enema for 20–30 m, bid] + conventional treatment | 31/30 | 8 weeks | SCr, BUN, Ccr |
| Wang and Xian-Qin 2007 [33] | Sodium Tanshinone II A sulfonate Injection (20 ml ivgtt qd) + conventional treatment | Conventional treatment | 31/28 | 2 months | FIB effective rate, SCr |
| Gao and Gao 2011 [34] | Sodium Tanshinone II A sulfonate injection (50 mgivgtt qd) + conventional treatment | Conventional treatment | 48/42 | 4 weeks | BUN, Ccr SCr, BUN, 24 h |
| Wang 2014 [35] | Sodium Tanshinone II A sulfonate injection (40 mg ivgtt qd) + Alprostadil injection (10 μg ivgtt qd) + conventional treatment | Conventional treatment | 32/32 | 28 days | UPE, CySC, CRP, FIB SCr, BUN, GFR |
| Tian et al. 2005 [36] | Salvia miltiorrhiza injection (60 ml ivgtt qd) + conventional treatment | Conventional treatment | 106/96 | 10 days | Adverse effect SCr, Ccr |
| Peng et al. 2010 [37] | Sodium tanshinone II A sulfonate injection (50 mg ivgtt qd) + Haikunshenxi capsule (2 pills p.o. tid) + conventional treatment | Conventional treatment | 30/28 | 3 weeks | SCr, BUN, Ccr |
| Xu et al. 2012 [38] | Salvia miltiorrhiza injection (1200 mg ivgtt qd) + Haikunshenxi capsule (2 pills p.o. tid) + conventional treatment | Conventional treatment | 30/30 | 15 days | Effective rate, SCr,BUN, 24 h, UPE, ALB, Ccr, Hb |
| Peng et al. 2010 [39] | Salvianolate injection (200 mg ivgtt qd) + Alprostadil | Conventional treatment | 29/28 | 2 weeks | SCr, BUN, Ccr |
| Liu et al. [40] | Salvianolate injection (100 mg ivgtt qd) + alprostadil injection (20 μg ivgtt qd) + conventional treatment | Alprostadil injection (20 μgivgtt qd) + conventional treatment | 63/63 | 4 weeks | Effective rate, SCr,BUN, Ccr |
| Lv et al. 2006 [41] | Salvia miltiorrhiza tablet (4 pills tid p.o.) + Jieduxiezhuo II decoction 150 ml retention enema qd + conventional treatment | Jieduxiezhuo II decoction 150 ml retention enema qd + conventional treatment | 30/30 | 1 month | Effective rate, SCr, BUN, Hb |
| Guowei et al. 2016 [42] | Sodium Tanshinone II A sulfonate injection (40 mg ivgtt qd) + alprostadil injection (10 μg ivgtt qd) + conventional treatment | Conventional treatment | 27/15 | 2 weeks | Effective rate, SCr |
| Pang 2004 [43] | Salvia miltiorrhiza injection (30 ml ivgtt qd) + TCM decoction 200 ml retention enema bid + low molecular levo-anhydride injection (250 ml ivgtt qd) + conventional treatment | Conventional treatment | 20/20 | 12 | BUN, effective rate, SCr |
| Chen 2016 [44] | Salvianolate Injection (150 mg ivgtt qd + conventional treatment | Conventional treatment | 32/32 | 14 days | SCr, BUN, Ccr |
| Wang 2015 [45] | Salvianolate injection (100 mg ivgtt qd) + Valsartan (80 mg p.o. qd) + conventional treatment | Valsartan (80 mg p.o. qd) + conventional treatment | 45/45 | 2 weeks | SCr, BUN, 24 h UPE, CySC |
| Zhi et al. 2016 [46] | Salvianolate injection (200 mg ivgtt qd) + Shenshuaining granules (1 bag p.o. 3–4 times/day) + conventional treatment | Conventional treatment | 31/31 | 2 weeks | SCr, BUN, Ccr, adverse effect |
| Chen and Lu 2012 [47] | Salvia miltiorrhiza injection (0.8 g ivgtt qd) + sodium ferulate injection (0.3 g ivgtt qd) + conventional treatment | Conventional treatment | 36/32 | 5 weeks | Effective rate, SCr, BUN, Ccr, Hb |
| Xie et al. 2020 [48] | Sodium tanshinone II A sulfonate injection (50 mg ivgtt qd) + Corbrin capsule (2 g p.o. tid) + conventional treatment | Corbrin capsule (2 g p.o.tid) + conventional | 53/52 | 2 months | Effective rate, SCr, BUN, 24 h UPE |
T. treatment group; C. control group; p.o.: per os; qd: quaque die; tid: ter in die; ivgtt: injectio intiavenosus gutta; 24 h UPE: 24 hour urine protein excretion; GFR: glomerular filtration rate; Ccr. creatinine clearance; SCr: serum creatinine; BUN: Blood urea nitrogen; CysC. cystatin C; ALB: serum albumin; TC: serum total cholesterol; Hb: haemoglobin; FIB: plasma fibrinogen; and CRP: C-reactive protein.