Figure 4.

Effect of captopril and HOE140 on serum Ang II (a) and bradykinin (b) concentrations in castrated hypertensive rats. (a) Captopril decreased serum Ang II concentration. In female rats, compared to captopril, HOE140 increased serum Ang II concentration. (b) Captopril increased serum bradykinin concentration. In male rats, compared to captopril, HOE140 decreased serum bradykinin concentration. Data are shown as mean ± SE. ^∗∗P < 0.001. n (male control) = 7, n (male ACEI) = 5, n (male ACEI + HOE140) = 6, n (female control) = 6, n (female ACEI) = 5, and n (female ACEI + HOE140) = 8.