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. 2022 Jun 14;2022:9067167. doi: 10.1155/2022/9067167

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Copyright © 2022 Na Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of captopril and HOE140 on bone turnover markers in castrated hypertensive rats. (a) Captopril increased rat urine DPD/Cr concentration. Compared to captopril, HOE140 decreased urine DPD/Cr in male rats. (b) Captopril increased rat serum OC concentration. Compared to captopril, HOE140 decreased osteocalcin concentration in male rats. Data are shown as mean ± SE. ^∗P < 0.05, ^∗∗P < 0.001. n (male control) = 7, n (male ACEI) = 5, n (male ACEI + HOE140) = 6, n (female control) = 6, n (female ACEI) = 5, and n (female ACEI + HOE140) = 8.