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Effect of captopril and HOE140 on cancellous BMD and bone microarchitecture parameters. (a–f) Captopril increased cancellous BMD, BV/TV, and Tb.N and decreased Tb.Sp in both female and male castrated hypertensive rats (P < 0.05). HOE140 further increased cancellous BMD and BV/TV. (g) 3-D morphometry of proximal femoral cancellous bone. Data are shown as mean ± SE. ∗P < 0.05, ∗∗P < 0.001. n = 3.
