Table 1.

Laboratory investigations during the first half of hospital admission

Variable	Reference range	Day 1	Day 3	Day 6	Day 9*	Day 12
Haematology
Haemoglobin (g/L)	135–172	102	99	101	85	78
White cells (× 109/L)	3.9–10.2	4.7	6.4	6.9	8.3	9.7
Differential count (× 109/L)
Lymphocytes	1.1–4.5	0.49	0.45	0.77	1.78	3.30
Basophils	0–0.2	0.02	0.00	0.00	0.13	0.00
Eosinophils	0.02–0.5	0.24	0.32	0.74	0.27	0.19
Monocytes	0.1–0.9	0.42	0.96	0.49	0.56	0.29
Neutrophils	1.5–7.7	3.23	4.67	3.98	4.73	5.72
Platelets (× 109/L)	150–370	141	115	144	116	151
Prothrombin time international normalised ratio	1–1.15	1.45	–	1.83	1.39	1.20
Fibrinogen (g/L)	1.46–3.33	–	2.71	2.45	2.12	1.11
Biochemistry
Sodium (mmol/L)	133–146	130	129	126	136	137
Potassium (mmol/L)	3.5–5.3	4.2	4.8	5.5	4.9	4.7
Urea (mmol/L)	2.5–7.8	12.4	15.5	28.7	11.8	31.0
Creatinine (μmol/L)	62–115	202	311	594	137	250
Alanine transaminase (U/L)	10–49	43	60	105	122	94
Alkaline phosphatase (U/L)	30–130	127	223	428	910	717
Albumin (g/L)	35–50	32	27	22	17	23
Total bilirubin (μmol/L)	0–20	12	34	117	98	46
Tacrolimus (μg/L)	5–8	> 30	25.5	11.3	5.1	3.6
C-reactive protein (mg/L)	0–6	256	276	309	235	53
Procalcitonin (ng/mL)	0–0.5	6.13	–	–	13.25	12.59
Ferritin (μg/L)	22–322	–	3164.7	8937.9	8829.9	2640.0
Triglyceride (mmol/L)	0.3–1.8	–	1.61	1.74	1.82	3.82
Interleukin-1 beta (pg/mL)	0–3.1	–	–	2.04	0.10	–
Interleukin-6 (pg/mL)	0–2	–	–	434.31	8.82	–
Interleukin-10 (pg/mL)	0–1	–	–	20.99	14.59	–
Tumour necrosis factor alpha (pg/mL)	0–5	–	–	250.19	66.82	–
Interferon gamma (pg/mL)	0–10	–	–	52.84	7.81	–
Virology
Nasopharyngeal SARS-CoV-2 (cycle threshold)	N/A	27	–	–	–	15
EBV PCR	N/A	1.3 × 107	–	–	–	–
Urine analysis
Blood	N/A	Neg	Trace	–	–	Trace
Leukocytes	N/A	Neg	Neg	–	–	Neg
Protein	N/A	–	3 +	–	–	Neg

*48 h post RTX administration and commencement of dexamethasone