Table I.

RASopathies associated with cutaneous manifestations

Syndrome	Common gene sequence variations	Possible cutaneous manifestations
Noonan syndrome∗	PTPN11, SOS1	Woolly or curly hair, plantar hyperkeratosis, ichthyosis, koilonychias, and multiple pigmented nevi, keratosis pilaris, sparse eyebrows, UO5
CFC syndrome∗	BRAF, MAP2K1, MAP2K2, KRAS	Multiple melanocytic nevi, hair abnormalities; curly wavy, or scarce hair; keratinization disorders (KP, UO, palmoplantar hyperkeratosis)2
Costello syndrome‡	HRAS	Loose, redundant skin; cutaneous papillomas, palmoplantar hyperkeratosis, sparse eyebrows, keratosis pilaris2
Cornelia de Lange syndrome†	Various chromosomal rearrangements	Confluent eyebrows, curly eyelashes, general hirsutism, UO6
Rubinstein-Taybi syndrome†‡	CREBBP	Hirsutism, keloid formation, capillary hemangiomas, café-au-lait spots, abnormal dermatoglyphics, pilomatricomas, keratosis pilaris4
Swyer syndrome‡§	MAP3K1	Sparse eyebrows, UO, keratosis pilaris, facial skin tags

CFC, Cardiofaciocutaneous syndrome; KP, keratosis pilaris; UO, ulerythema ophryogenes.

^∗Strong association with cutaneous manifestations listed, including UO.

^†Moderate association with cutaneous manifestations listed.

^‡Possible association with UO.

^§Present case.