Fig. 2.

Inflammatory biomarkers. Mean inflammatory biomarker values at baseline and Day 28 for patients in the tocilizumab (green) and comparison (red) groups. Cytokine values are summarized by geometric mean/SD and analyzed on a log10 scale. Interleukins 2 and 4 (IL-2 and IL-4), interferon-gamma (IFN-g), and tumor necrosis factor-alpha (TNF-a) were removed from the analyses due to the high prevalence of values below the limit of detection. CRP = c-reactive protein; IL-10 = interleukin 10; IL-17A = interleukin 17A; IL-1ra = interleukin 1 receptor antagonist; IL-6 = interleukin 6; IL-6R = interleukin 6 receptor. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)