Table 3.
Relationship between baseline inflammatory biomarkers and Day 28 depression. ANCOVA models of Day 28 depression score based on individual baseline cytokines, adjusted for clinical covariates.
| Characteristic | CRP |
IL10 |
IL6 |
IL6R |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| Baseline Depression | 0.44 | −0.12, 1.0 | 0.12 | 0.34 | −0.26, 0.94 | 0.3 | 0.39 | −0.14, 0.92 | 0.14 | 0.40 | −0.12, 0.93 | 0.13 |
| Cytokine, 10-fold increase | −2.0 | −11, 7.4 | 0.7 | 1.6 | −5.8, 9.0 | 0.7 | −1.3 | −9.3, 6.8 | 0.8 | −3.4 | −24, 17 | 0.7 |
| Conditioning (RIC/NST vs MAC) | −9.8 | −18, −1.9 | 0.017 | −9.4 | −17, −1.3 | 0.025 | −9.3 | −18, −0.87 | 0.032 | −9.3 | −18, −1.1 | 0.028 |
| Remission status (CR1 vs not) | −1.0 | −8.9, 6.8 | 0.8 | −1.5 | −9.6, 6.7 | 0.7 | −1.0 | −8.9, 6.9 | 0.8 | −0.88 | −8.8, 7.0 | 0.8 |