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. 2022 Jun 11;23:100480. doi: 10.1016/j.bbih.2022.100480

Table 3.

Relationship between baseline inflammatory biomarkers and Day 28 depression. ANCOVA models of Day 28 depression score based on individual baseline cytokines, adjusted for clinical covariates.

Characteristic CRP
IL10
IL6
IL6R
Beta 95% CI1 p-value Beta 95% CI1 p-value Beta 95% CI1 p-value Beta 95% CI1 p-value
Baseline Depression 0.44 −0.12, 1.0 0.12 0.34 −0.26, 0.94 0.3 0.39 −0.14, 0.92 0.14 0.40 −0.12, 0.93 0.13
Cytokine, 10-fold increase −2.0 −11, 7.4 0.7 1.6 −5.8, 9.0 0.7 −1.3 −9.3, 6.8 0.8 −3.4 −24, 17 0.7
Conditioning (RIC/NST vs MAC) −9.8 −18, −1.9 0.017 −9.4 −17, −1.3 0.025 −9.3 −18, −0.87 0.032 −9.3 −18, −1.1 0.028
Remission status (CR1 vs not) −1.0 −8.9, 6.8 0.8 −1.5 −9.6, 6.7 0.7 −1.0 −8.9, 6.9 0.8 −0.88 −8.8, 7.0 0.8