Table 2. Previous reports of signet-ring cell/histiocytoid carcinoma of the eyelid.
A total of 14 cases were presented, including the previously reported 13 cases and our case. It often occurs in elderly males and has a long disease duration of 6-24 months. Surgical treatment is performed in all cases described in detail, and recurrence is observed in six cases.
M - male; F - female; ND - not described; OP - operation; PORT - postoperative radiation therapy; POCRT - postoperative chemoradiation therapy.
| Author | Year | Age | Sex | Disease duration | Metastasis | Treatment | Recurrence | Genetic mutation |
| Requena L [1] | 2011 | 65 | M | 24 months | No | OP+PORT | Yes | |
| 76 | M | 24 months | No | none | No | |||
| 78 | M | 12 months | No | OP+PORT | No | |||
| 59 | F | 12 months | No | OP+PORT | Yes | |||
| 84 | M | ND | No | OP | ND | |||
| Iwaya M [9] | 2012 | 72 | M | 6 months | No | OP+POCRT(S-1) | Yes | |
| Jantima T [12] | 2013 | 74 | M | ND | No | ND | No | |
| Bernárdez C [5] | 2016 | 78 | M | ND | No | ND | No | |
| Sakamoto K [6] | 2017 | 74 | M | ND | ND | OP | Yes | |
| Palakkamanil MM [7] | 2020 | 73 | M | 24 months | No | OP+PORT | No | |
| Raghavan SS [8] | 2020 | 85 | M | 18 months | Yes | OP+PORT+Tamoxifen | No | NTRK3,CDH1,CDKN1B,PIK3CA |
| Stewart S [10] | 2020 | 84 | M | 24 months | ND | OP | Yes | |
| Jakobiec FA [11] | 2020 | 88 | M | 6 months | No | OP+PORT | No | CDH1 |
| Our case | 64 | M | 12 months | Yes | OP | Yes | CDH1,ERBB2,NF1,TP53 |