Table 5.

Effect of RIPC and nitrates (either intraoperative IV GTN or long-lasting oral nitrates) on all-cause mortality up to 12 months following surgery for ERICCA post-hoc analysis

	Unadjusteda				Adjustedb
	HR	95% CI		p value	HR	95% CI		P value
Interaction nitrates*RIPC	2.78	1.27	6.09	0.010	2.88	1.31	6.32	0.008
Effect of RIPC in strata
No nitrates	0.85	0.52	1.40	0.529	0.91	0.55	1.51	0.714
Nitrates	2.37	1.30	4.31	0.005	2.62	1.43	4.79	0.002
Comparison of each combination
Control (sham RIPC without nitrates) (ref)
RIPC alone	0.85	0.52	1.40	0.529	0.91	0.55	1.51	0.714
Nitrates alone	0.79	0.41	1.53	0.482	0.83	0.43	1.60	0.572
RIPC + Nitrates	1.87	1.07	3.28	0.029	2.16	1.22	3.82	0.008

HR, hazard ratio; CI, confidence interval

^aCox Proportional hazards model with stratification by study site

^bCox Proportional hazards model with stratification by study site and adjustment for EuroSCORE, body mass index (BMI), previous myocardial infarction, and diabetes