Table 7.
Effect of RIPC and nitrates (either intraoperative IV GTN or long-lasting oral nitrates) on perioperative myocardial infarction for ERICCA post-hoc analysis
Unadjusted | Adjusteda | |||||||
---|---|---|---|---|---|---|---|---|
OR | 95% CI | p value | OR | 95% CI | p value | |||
Interaction nitrates * RIPC | 1.78 | 1.06 | 3.00 | 0.029 | 1.82 | 1.08 | 3.06 | 0.025 |
Effect of RIPC in strata | ||||||||
No nitrates | 0.70 | 0.51 | 0.96 | 0.025 | 0.69 | 0.50 | 0.95 | 0.025 |
Nitrates | 1.24 | 0.83 | 1.87 | 0.299 | 1.26 | 0.84 | 1.89 | 0.271 |
Comparison of each combination | ||||||||
Control (sham RIPC without nitrates) (ref) | ||||||||
RIPC alone | 0.70 | 0.51 | 0.96 | 0.025 | 0.69 | 0.50 | 0.95 | 0.025 |
Nitrates alone | 0.68 | 0.46 | 1.01 | 0.056 | 0.69 | 0.46 | 1.03 | 0.069 |
RIPC + Nitrates | 0.84 | 0.57 | 1.24 | 0.386 | 0.87 | 0.59 | 1.28 | 0.481 |
OR, odds ratio; CI, confidence interval
aAdjusted for EuroSCORE, body mass index (BMI), previous myocardial infarction, and diabetes