Table 8.
Effect of RIPC and nitrates (either intraoperative IV GTN or long-lasting oral nitrates) on peri-operative myocardial injury for ERICCA post-hoc analysis
| Unadjusted# | Adjusted#* | |||||||
|---|---|---|---|---|---|---|---|---|
| Ratio | 95% CI | p value | Ratio | 95% CI | p value | |||
| Interaction nitrates * RIPC | 1.07 | 0.92 | 1.25 | 0.358 | 1.09 | 0.94 | 1.26 | 0.276 |
| Effect of RIPC in strata | ||||||||
| No nitrates | 0.93 | 0.84 | 1.04 | 0.190 | 0.93 | 0.84 | 1.03 | 0.185 |
| Nitrates | 1.00 | 0.89 | 1.13 | 0.983 | 1.01 | 0.90 | 1.14 | 0.820 |
| Comparison of each combination | ||||||||
| Control (sham RIPC without nitrates) (ref) | ||||||||
| RIPC alone | 0.93 | 0.84 | 1.04 | 0.190 | 0.93 | 0.84 | 1.03 | 0.185 |
| Nitrates alone | 0.93 | 0.83 | 1.05 | 0.251 | 0.95 | 0.85 | 1.06 | 0.361 |
| RIPC + Nitrates | 0.94 | 0.83 | 1.06 | 0.292 | 0.96 | 0.85 | 1.09 | 0.528 |
CI, confidence interval. Ratio, ratio of geometric mean 72-h AUC hs-TnT
*Adjusted for EuroSCORE, body mass index (BMI), previous myocardial infarction, and diabetes
#Results using multiple imputation dataset