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. 2022 May 30;36(6):633–647. doi: 10.1007/s40263-022-00926-0

Table 3.

Average total nightly dose of LXB during SDP, time to reach stable total nightly dose, and number of LXB dose adjustments in participants who achieved a stable dose of LXB, by treatment at study entry (efficacy population)

Group A Group B Group C Group D Total (N = 134)
SXB only (n = 41) SXB + other anticataplectics (n = 14) Other anticataplectics (n = 21) Anticataplectic naive (n = 58)
Average total nightly dose of LXB (g/night)
 Mean 7.6 8.3 7.4 6.9 7.3
 SD 1.4 1.1 1.3 1.5 1.4
 Median 7.5 9.0 7.5 7.0 7.5
 Minimum, maximum 4.5, 9.0 6.0, 9.0 4.5, 9.0 3.0, 9.0 3.0, 9.0
Time to reach stable total nightly dose (days)
 Mean 14.5 15.7 45.5 39.0 30.1
 SD 21.37 24.59 18.57 20.86 24.56
 Median 1.0 1.0 50.0 36.5 29.0
 Minimum, maximum 1, 84 1, 64 5, 73 1, 81 1, 84
Number of dose adjustments to reach stable total nightly dose
 Mean 1.0 0.8 3.5 2.6 2.1
 SD 1.99 1.48 1.47 1.35 1.87
 Median 0.0 0.0 3.0 3.0 2.0
 Minimum, maximum 0, 8 0, 5 1, 7 0, 6 0, 8

LXB lower-sodium oxybate, SD standard deviation, SDP stable-dose period, SXB sodium oxybate