Table 3.

Severity of CIA distress measured with the CADS questionnaire

	45-min PICT	20-min PICT	p value
Baseline
Median total score (range)	5.0 (0–23)	4.0 (0–20)	0.80
Low distress (n (%))	23 (92.0)	25 (92.6)	0.94
High distress (n (%))	2 (8.0)	2 (7.4)
Cycle 3
Median total score (range)	2.0 (0–21)	5.0 (0–19)	0.31
Low distress (n (%))	17 (89.5)	18 (85.7)	0.85
High distress (n (%))	2 (10.5)	3 (14.3)
Cycle 6
Median total score (range)	6.5 (0–25)	6.0 (0–23)	0.81
Low distress (n (%))	16 (88.9)	16 (88.9)	1.00
High distress (n (%))	2 (11.1)	2 (11.1)
	Successful scalp cooling n (%)	Unsuccessful scalp cooling n (%)	p value
Baseline
Median total score (range)	4.5 (0–20)	6 (0–23)	0.39
Low distress (n (%))	29 (90.6)	11 (91.7)
High distress (n (%))	3 (9.4)	1 (8.3)	0.97
Cycle 3
Median total score (range)	2.5 (0–17)	8.5 (0–21)	< 0.01
Low distress (n (%))	29 (96.7)	6 (60.0)
High distress (n (%))	1 (3.3)	4 (40.0)	0.09
Cycle 6
Median total score (range)	4.0 (0–14)	12 (2–25)	< 0.01
Low distress (n (%))	26 (96.3)	6 (66.7)
High distress (n (%))	1 (3.7)	3 (33.3)	0.19

The CADS’ total score ranges from 0 to 51, low distress: 0–13 score, high distress: score of 14 or above

CIA Chemotherapy-induced alopecia, CADS chemotherapy-induced alopecia distress scale, PICT post-infusion cooling time