Table 1.

Baseline patient characteristics and interventions

	Patient No. 1 71 years, male	Patient No. 2 59 years, male	Normal range
Paraprotein Type of monoclonal gammopathy	IgG-kappa SMM	IgG-kappa Solitary plasmacytoma with minimal marrow involvement	–
Bone marrow plasma cells (in %)	50	5	–
aPTT	50.9 s	42.6 s	27.0–41.0 s
FVIII activity (in %)	14	15	60–230
vWF:Ag activity (in %)	10	17	60–180
vWF:Act (in %)	4	21	48–170
vWF:Rco (in %)	10	< 10	60–180
vWF multimer studies	No large multimers present	Normal distribution pattern	–
Bleeding symptoms	Extensive bleeding history including life-threatening hemorrhagic shock during mechanical ventilation	Perisurgical hematoma following surgery for pathological femoral fracture	–
Intervention	Antimyeloma treatment	Antimyeloma treatment and ASCT	–
Outcome	Complete normalization of coagulation studies, no further bleeding complications	Complete normalization of coagulation studies, no further bleeding complications	–

MGUS monoclonal gammopathy of undetermined significance, SMM smoldering multiple myeloma, aPTT activated partial thromboplastin time, FVIII factor VIII, vWF:Ag von Willebrand factor antigen, vWF:Act von Willebrand factor activity, vWF:RCo von Willebrand factor ristocetin cofactor activity