Table 3.
Assessment of the weight dependence of various homoarginine dosing regimens; given percentage indicate the number of subjects laying > 90% of time in target range
| Population | Old | Old | Old | Young | Young | Young |
|---|---|---|---|---|---|---|
| Dosing regimen | 60 kg ± 0.5 kg | 80 kg ± 0.5 kg | All | 60 kg ± 0.5 kg | 80 kg ± 0.5 kg | all |
| 12.5 mg q 24 h | 67.5% | 37.2% | 50.4% | 71.5% | 38.4% | 54.3% |
| 15 mg q 24 h | 80.9% | 47.0% | 63.7% | 84.2% | 47.6% | 67.6% |
| 20 mg q 24 h | 87.6% | 70.7% | 79.6% | 92.6% | 76.2% | 84.1% |
| 25 mg q 24 h | 60.4% | 79.3% | 74.1% | 73.8% | 84.1% | 82.2% |
| 125 mg q 168 h | 0.33% | 20.1% | 9.0% | 17.4% | 24.4% | 22.1% |