Table 5.
Propensity score weighted analysis on the use of rescue therapy from days 1 to 5
| Variables1 | Odds ratio2 | 95%CI | Impact on need for rescue therapy |
|---|---|---|---|
| NK1 group (vs. CINVANTI®) | |||
| IV EMEND® | 2.69 | (1.06 to 6.84) | ↑ likelihood by 2.7 times |
| Generic alternatives | 0.68 | (0.22 to 2.07) | NS |
| Cycle 1 vs. ≥ cycle 2 | 2.04 | (1.11 to 3.73) | ↑ likelihood by 2.0 times |
| Carboplatin given | 2.68 | (1.07 to 6.70) | ↑ likelihood by 2.7 times |
| Patient age | 0.96 | (0.93 to 0.98) | ↓ likelihood in older patients |
| Adjusted R^2 statistic3 | 10.8% | ||
Dependent variable: documented use of rescue therapy
Abbreviations: NK1 neurokinin 1 receptor antagonist, CVA central venous access, CINV chemotherapy-induced nausea and vomiting
1These are the final variables that were retained following the application of the likelihood ratio test (p < 0.05 to retain) in a backwards elimination process
2An odds ratio of less than one indicates lower likelihood and greater than one an increased likelihood
3This is the proportion of variability in the dependent variables than is accounted for by the independent variables