Table 3.

Diagnostic features of individual mEPE features included in PI-RADS v2.1

		Diagnostic parameters				Univariate BLR
	Detection rate	Sensitivity	Specificity	PPV	NPV	p	Odds ratio
Capsular abutment	45/97 (46%)	1	0.07 (0.004–0.14)	0.46	1	0.98	n.d.
Tumor-capsule interface > 10 mm	23/31 (74%)	0.51 (0.365–0.66)	0.86 (0.77–0.95)	0.74	0.69	0.00015	6.3 (2.4–16)
Irregular or spiculated margin	33/53 (62%)	0.73 (0.60–0.86)	0.64 (0.52–0.77)	0.62	0.75	0.0003	4.95 (2.1–12)
Bulging prostatic contour	31/37 (84%)	0.69 (0.55–0.82)	0.89 (0.81–0.97)	0.80	0.848	< 0.0001	18.5 (6.4–53)
Asymmetry of neurovascular bundle	11/13 (85%)	0.24 (0.12–0.37)	0.96 (0.92–1)	0.85	0.61	0.007	8.7 (1.8–42)
Measurable extraprostatic disease	9/9 (100%)	0.2 (0.08–0.32)	1	1	0.61	0.98	n.d.
Obliteration of recto-prostatic angle	4/4 (100%)	0.09 (0.006–0.17)	1	1	0.58	0.98	n.d.

mEPE, suspicion of extraprostatic extension at MRI; BLR, binary logistic regression; PPV, positive predictive value; NPV, negative predictive value; n.d., not determined, interval extending from 0 to infinite