Fig. 6.

BMS309403 and anagliptin reduce FABP4 expression in murine synovial macrophages. a–c Representative images and quantification of FABP4 immunohistochemical staining and coimmunostaining of FABP4 with F4/80 or NOS2 in the synovium of TSC1KO mice treated with vehicle, BMS309403 or anagliptin for 4 and 8 weeks after AIA modeling (n = 10 per group). Scale bar: 12.5 µm and 100 µm. d–f Representative images and quantification of FABP4 immunohistochemical staining and coimmunostaining of FABP4 and F4/80 or NOS2 in the synovium of RA mice treated with vehicle or BMS309403 for 4 and 8 weeks (n = 10 per group). Scale bar: 12.5 µm and 100 µm. Student’s t-test or one-way ANOVA and Tukey’s multiple comparison test. ^*P < 0.05, ^**P < 0.01. The data are shown as the mean ± SEM