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. 2022 Jun 21;14:30. doi: 10.1038/s41368-022-00184-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — circ_0003204 inhibited hASC osteogenesis through sponging miR-370-3p. a Bioinformatic analysis predicted the target relationship. b RT-qPCR evaluated the expression of miR-370-3p. c The putative binding sequences. d Luciferase reporter genes were co-transfected with miR‐370‐3p mimic/mimic-NC and mut-type/wild-type circ_0003204 into cells, and the luciferase activities were measured. e RT-PCR evaluated the expression of circ_0003204 and miR-370-3p. f Images of ALP and ARS stainings after transfection. g, h ALP and ARS activity analyses were measured. i RT-qPCR evaluated the mRNA expressions after 7-day osteogenic induction of hASCs (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1)