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. 2022 Jun 21;6:40. doi: 10.1038/s41698-022-00283-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Diagram showing circulating lncRNAs reported in the literature regrouped by cancer type. Some lncRNAs (in black letters) are cancer-specific. Other circulating lncRNAs (in white letters) such as MALAT1, SPRY4-IT1, PVT1, UCA1 and LINC00152 reflect tumorigenesis in multiple organs. b Simplified cartoon representing the specificity of certain circulating lncRNAs towards cancers of organs located in designated anatomic segments of the human body. c Gene tissue expression of some of the most widely reported circulating lncRNAs with high multicancer diagnosis potential (GTEx, obtained from UCSC genome browser^188–197, https://genome.ucsc.edu/).