Table 3.
Comparative clinical data grouped by cutoff value (15.33 pg/ml) in patients with sepsis.
| Low Sirt3 (n = 25) | High Sirt3 (n = 26) | P value | |
|---|---|---|---|
| HR (bpm) | 94.8 ± 17.98 | 90.57 ± 16.97 | 0.392 |
| MAP (mmHg) | 84.04 ± 10.53 | 80.92 ± 9.11 | 0.263 |
| CVP (cmH2O) | 7.48 ± 2.16 | 7.84 ± 2.57 | 0.585 |
| OI | 305.18 ± 109.72 | 295.21 ± 138.59 | 0.778 |
| HB (g/l) | 99.68 ± 31.21 | 98.85 ± 22.83 | 0.913 |
| RASS | − 1.96 ± 1.43 | − 2.58 ± 1.55 | 0.372 |
| NE (ug/kg/min) | 0.23 (0.056,0.49) | 0.096 (0,0.231) | 0.203 |
| PEEP (ml/cmH2O) | 5 (5,6.75) | 5 (4.5,8) | 0.873 |
| Diagnosis (n,%) | |||
| Sepsis | 13 (52%) | 22 (84.6%) | |
| Septic shock | 12 (48%) | 4 (15.4%) | |
| Severity of illness | |||
| SOFA score | 12.84 ± 2.68 | 8.69 ± 3.27 | < 0.001*** |
| APACHE II score | 21.2 ± 7.97 | 16.8 ± 7.00 | 0.045* |
| Length of ICU stay (days) | 8 (5,10) | 14 (8,29) | 0.035* |
| Length of hospital stay (days) | 26 (14.5,40.75) | 27.5 (14,42.25) | 0.713 |
| Perfusion indicators | |||
| P(V-A)CO2 (mmHg) | 2.5 (1.625,4.775) | 3.5 (1.45,4.6) | |
| Lactate (mmol/l) | 1.9 (1.5,4.6) | 1.25 (1,2.025) | 0.003* |
| ScvO2 (%) | 79.16 ± 6.86 | 69.78 ± 8.14 | < 0.001*** |
| Laboratory parameters of infection | |||
| PCT ( (ng/ml)) | 68 (13,87) | 2.45 (0.675,9.4) | 0.019* |
| Hs-CRP (mg/l) | 190 (188.41,190) | 190 (190,190) | 0.865 |
| WBC (109) | 11.37 ± 7.52 | 13.62 (7.8,17.05) | 0.137 |
| Inflammatory cytokines | |||
| TNF-α (mg/l) | 24.56 (18.35,34.15) | 24.37 (12.87,24.55) | 0.033* |
| IL-10 (pg/ml) | 75.53 (15.6,86.763) | 35 (6.15,86.76) | 0.144 |
| IL-8 (pg/ml) | 278.5 (85.25,366) | 197 (74.75,366) | 0.315 |
| IL-6 (pg/ml) | 209.6 (108,244) | 137.5 (39.73,209.6) | 0.024* |
Values are expressed as mean ± standard deviation, median (interquartile range), or number (percentage).*denotes P < 0.05, ***denotes P < 0.001
MAP mean arterial pressure, HR heart rate, CVP Central venous pressure, OI oxygenation index, SOFA Score Sequential Organ Failure Assessment Score, APACHE II score Acute Physiology and Chronic Health Evaluation II score, P(V-A)CO2 central venous-to-arterial carbon dioxide difference, HB Hemoglobin, NE Norepinephrine, RASS Richmond Agitation-Sedation Scale, P(CV-A)CO2 central venous-to-arterial blood carbon dioxide partial pressure, ScvO2 Central venous oxygen saturation, OI oxygenation index, PCT procalcitonin, Hs-CRP high-sensitivity C-reactive protein, WBC white blood cell, TNF-α Tumor Necrosis Factor α, IL-10 Interleukin-10, IL-8 Interleukin-8, IL-6 Interleukin-6.