Table 1.
List of significantly associated genes from TWAS.
| Chromosome | Gene | Panel | eQTL.ID | Z (TWAS) | P (TWAS) | P (Permutation) |
|---|---|---|---|---|---|---|
| CRNN | Skin - not sun exposed (suprapubic) | rs4845763 | 4.9853 | 6.19E−07 | 0.1875 | |
| FLG | Cells - transformed fibroblasts | rs1552991 | −6.244 | 4.27E−10 | 0.0498 | |
| Skin - sun exposed (lower leg) | rs11204948 | −7.4583 | 8.77E−14 | 0.0325 | ||
| Thyroid | rs4845737 | −7.1502 | 8.67E−13 | 0.0194 | ||
| Skin - not sun exposed (suprapubic) | rs1552991 | −6.6973 | 2.12E−11 | 0.0328 | ||
| Cells - transformed fibroblasts | rs1552991 | −6.5511 | 5.71E−11 | 0.0188 | ||
| 1 | FLG-AS1 | Skin - sun exposed (lower leg) | rs4845743 | −5.9174 | 3.27E−09 | 0.0335 |
| Spleen | rs4845737 | −5.5863 | 2.32E−08 | 0.0822 | ||
| Thyroid | −6.4987 | 8.10E−11 | 0.0353 | |||
| IL6R | Whole blood | rs4845618 | −4.9217 | 8.58E−07 | 0.0152 | |
| YFS blood | rs4845623 | −5.2654 | 1.40E−07 | 0.0108 | ||
| LINGO4* | Skin - not sun exposed (suprapubic) | rs12128071 | 5.6211 | 1.90E−08 | 0.0307 | |
| RFX5* | Thyroid | rs6684085 | −4.9048 | 9.35E−07 | 0.2308 | |
| 2 | AC007278.2 | Whole blood | rs1420106 | −6.14 | 8.50E−10 | 0.0004 |
| AC007248.7 | Whole blood | rs13015714 | 5.31 | 1.09E−07 | 0.0011 | |
| IL1RL1 | NTR blood | rs7559479 | −5.7959 | 6.80E−09 | 0.0123 | |
| IL18RAP | Whole blood | rs3755267 | −5.99 | 2.09E−09 | 0.0015 | |
| YFS blood | rs3755266 | −5.0088 | 5.48E−07 | 0.0085 | ||
| 5 | KIF3A | Skin - sun exposed (lower leg) | rs3213639 | −5.1391 | 2.76E−07 | 0.1111 |
| P4HA2* | Cells - transformed fibroblasts | rs4705928 | −5.085 | 3.68E−07 | 0.4444 | |
| 10 | RBM17* | Skin - sun exposed (lower leg) | rs8463 | −5.6682 | 1.44E−08 | 0.005 |
| 11 | OVOL1 | Cells - EBV-transformed lymphocytes | rs10791824 | −5.6193 | 1.92E−08 | 0.001 |
| 14 | FAM177A1 | Skin - not sun exposed (suprapubic) | rs11156875 | 5.0543 | 4.32E−07 | 0.0157 |
| PPP2R3C | NTR blood | rs8014377 | −5.3214 | 1.03E−07 | 0.0066 | |
| RP11-85K15.2 | Whole blood | rs13379372 | 5.3018 | 1.15E−07 | 0.0239 | |
| 16 | CLEC16A | Thyroid | rs2286975 | 5.0211 | 5.14E−07 | 0.0478 |
| 17 | FAM134C | Skin - not sun exposed (suprapubic) | rs2293158 | −4.9214 | 8.59E−07 | 0.0026 |
| 20 | ARFRP1 | Cells - transformed fibroblasts | rs4809330 | 6.8397 | 7.93E−12 | 0.0019 |
| Thyroid | rs2315008 | 5.8079 | 6.33E−09 | 0.0082 | ||
| Whole blood | rs6062504 | −5.5349 | 3.11E−08 | 0.0062 | ||
| LIME1 | Skin - sun exposed (lower leg) | rs6011040 | −5.2138 | 1.85E−07 | 0.1304 | |
| Whole blood | rs4809330 | −5.3781 | 7.53E−08 | 0.0227 | ||
| YFS blood | rs6011058 | −6.1045 | 1.03E−09 | 0.0064 | ||
| SLC2A4RG | Thyroid | rs1151622 | 6.0395 | 1.55E−09 | 0.0197 | |
| STMN3 | Skin - sun exposed (lower leg) | rs2315008 | −5.5004 | 3.79E−08 | 0.0102 | |
| Whole blood | rs6011040 | 5.43 | 5.64E−08 | 0.0093 | ||
| ZBTB46 | Thyroid | rs2315654 | 6.9417 | 3.87E−12 | 0.0015 | |
| ZGPAT | Cells - transformed fibroblasts | rs1058319 | 5.3406 | 9.26E−08 | 0.0086 |
Genes marked with asterisks are novel genes that were not identified in the original GWAS study.