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. 2022 Jun 21;12:10479. doi: 10.1038/s41598-022-14326-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Porcine skin samples were imaged with a PS-OCT system after burn induction. OCT intensity images are shown for a representative cross-sectional view (a) and superficial en face view (b) for an ROI spanning a tissue region subject to 30 s burn duration (left side of each panel), no burn (center of each panel), and 60 s burn duration (right side of each panel). The degree of polarization (DOP) was spatially mapped throughout each cross-section (c). The surface of each tissue section was identified automatically and a DOP threshold was applied to determine the depth extent of the injured collagen in each cross section (white dashed lines). The difference between these two lines [e.g., orange arrow in (c)], adjusted by tissue refractive index, was used to calculate the collagen injury depth for each cross section of the imaged volume to produce an en face map of DOP-based collagen injury depth (d) corresponding to the same ROI as (b). Scale bars = 1 mm. Intensity limits for 2D colorbars in (c) and (d) range from 0 dB to 50 dB.