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. 2022 Jun 21;13:3544. doi: 10.1038/s41467-022-31149-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a IL-1β levels in serum from septic mice measured by ELISA. (n = 9; mean ± SEM) (b) IL-1α and IL-6 levels in serum from septic mice measured by ELISA. (n = 9, mean ± SEM) (c) Survival rates of sepsis model mice (n = 15, log-rank test [Mantel–Cox]). d IL-1β levels in serum from septic mice measured by ELISA (Kcnj2^f/f, n = 12; Lyz2-cre-Kcnj2^f/f, n = 13; mean ± SEM). e Survival rates of sepsis model mice (n = 13; log-rank test [Mantel–Cox]). f IL-1β levels in serum from septic mice measured by ELISA (DMSO, n = 8; ML133, n = 7; Kcnj2^f/f, n = 12, Lyz2-cre-Kcnj2^f/f, n = 11; mean ± SEM). g The expression of KCNJ2 in monocytes from healthy donors, sepsis patients, and those who recovered from sepsis with or without LPS⁶³. Data sourced from the GEO database (GSE46955). (n = 6, 8, 8 respectively; mean ± SEM). h Heatmap showing the expression of Kir2.1 and inflammatory genes in monocytes from septic patients and those who recovered from sepsis in response to LPS⁶³. Data sourced from the GEO database (GSE46955). (n = 8, 8 respectively; mean ± SEM). i Relative IL-1β levels in the supernatant of cultured synovial fluid cells from two gouty patients analyzed by ELISA. Two-tailed unpaired Student’s t-test. Source data are provided as a Source Data files.