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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Biol Psychiatry. 2021 Dec 22;92(3):236–245. doi: 10.1016/j.biopsych.2021.11.026

Figure 1.

Figure 1.

Study outline of the polygenic risk score (PRS) analyses. Our study used ABCD (Adolescent Brain Cognitive Development) Study data release 3.0, which included genetics and phenotypic data collected in the baseline and the first follow-up year for 11,877 participants. Suicidal data were collected using the youth version of the computerized Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5. Using the individual item data, we generated 3 lifetime suicide-related measures, encompassing nonsuicidal self-injury (NSSI), suicidal ideation (SI), and suicide attempt (SA). Well-known risk factors of suicide were included in the analysis using the ABCD Study survey data. For PRS data generation, 8 psychiatric disorder genome-wide association studies (GWASs) of the largest available sample size were applied to 4344 ABCD participants of European ancestry. SNP, single nucleotide polymorphism.