Table 2.

Logistic Regression Analysis Results of ADHD and Major Depression PRSs on Suicidality While Accounting for Demographic, Socioeconomic, and Family Risk Factors

Outcome/Independent Variable	OR	95% CI	Beta	SE	p Value	R 2
Suicide Attempts (Baseline)						1.87%
Age	0.92	0.66–1.29	−0.08	0.17	6.32 × 10−1
Sex	1.02	0.51–2.01	0.02	0.35	9.62 × 10−1
Marital status	0.61	0.28–1.35	−0.49	0.40	2.24 × 10−1
Parental education	0.85	0.59–1.21	−0.17	0.18	3.56 × 10−1
Household income	0.70	0.47–1.04	−0.36	0.20	7.53 × 10−2
Poverty	0.84	0.29–2.47	−0.17	0.55	7.54 × 10−1
Child psychopathology	2.67	1.89–3.77	0.98	0.18	2.21 × 10−8c
Family history of suicide	1.12	0.86–1.46	0.11	0.14	4.14 × 10−1
Major depression PRS	1.55	1.10–2.18	0.44	0.17	1.27 × 10−2a
Suicide Attempts (Year 1)						1.17%
Age	1.10	0.87–1.41	0.10	0.12	4.26 × 10−1
Sex	1.04	0.64–1.71	0.04	0.25	8.65 × 10−1
Marital status	0.64	0.36–1.15	−0.44	0.30	1.40 × 10−1
Parental education	0.83	0.64–1.07	−0.19	0.13	1.47 × 10−1
Household income	0.88	0.66–1.17	−0.13	0.15	3.69 × 10−1
Poverty	0.94	0.38–2.33	−0.06	0.46	8.96 × 10−1
Child psychopathology	2.61	2.03–3.35	0.96	0.13	7.73 × 10−14c
Family history of suicide	1.15	0.95–1.40	0.14	0.10	1.58 × 10−1
Major depression PRS	1.38	1.08–1.77	0.32	0.13	1.05 × 10−2a
Suicidal Ideation (Baseline)						0.13%
Age	0.90	0.81–1.00	−0.11	0.06	5.30 × 10−2
Sex	0.83	0.67–1.04	−0.18	0.11	1.07 × 10−1
Marital status	0.75	0.56–1.00	−0.29	0.15	4.78 × 10−2a
Parental education	0.95	0.84–1.07	−0.06	0.06	3.65 × 10−1
Household income	0.89	0.78–1.01	−0.12	0.07	7.58 × 10−2
Poverty	0.71	0.41–1.25	−0.34	0.28	2.36 × 10−1
Child psychopathology	1.59	1.43–1.77	0.46	0.05	< 2 × 10−16c
Family history of suicide	1.00	0.90–1.11	0.00	0.05	9.69 × 10−1
ADHD PRS	1.09	0.98–1.22	0.09	0.06	1.30 × 10−1
Suicidal Ideation (Year 1)						0.39%
Age	0.98	0.89–1.07	−0.02	0.05	6.46 × 10−1
Sex	0.98	0.82–1.19	−0.02	0.10	8.70 × 10−1
Marital status	0.84	0.65–1.08	−0.17	0.13	1.72 × 10−1
Parental education	0.97	0.88–1.08	−0.03	0.05	5.83 × 10−1
Household income	0.92	0.82–1.03	−0.08	0.06	1.46 × 10−1
Poverty	0.92	0.57–1.49	−0.08	0.24	7.43 × 10−1
Child psychopathology	1.70	1.55–1.87	0.53	0.05	< 2 × 10−16c
Family history of suicide	0.99	0.90–1.08	−0.01	0.05	8.20 × 10−1
ADHD PRS	1.15	1.05–1.26	0.14	0.05	3.71 × 10−3b

Beta and SE represent the logistic regression beta coefficient and its standard error. OR was calculated as the exponential of the logistic regression beta coefficient. 95% CI is the 95% confidence interval of OR. p value represents the significance of estimated beta using z-statistic. R² represents Nagelkerke’s pseudo R², which estimates the unique proportion of variance explained by PRSs.

ADHD, attention-deficit/hyperactivity disorder; OR, odds ratio; PRS, polygenic risk score.

^ap < .05.

^bp < .01.

^cp < .001.