Table 2:

Significant association of 41200.W231 status with diagnostic and operational codes (FDR q<0.05). Outcomes directly related to 41200.W231 were not reported. Full results are listed in Supplementary Table 2 and 3.

Code		41200.W231 cases (%)	matched controls (%)	OR	95% CI
ICD-10	M19.9 Arthrosis, unspecified	0.083	0.028	3.18	2.08–4.86
	F32.9 Depressive episode, unspecified	0.097	0.036	2.86	1.93–4.25
	E11.9 Without complications	0.117	0.049	2.57	1.79–3.69
	M81.99 Osteoporosis, unspecified (Site unspecified)	0.052	0.014	3.93	2.31–6.68
	N17.9 Acute renal failure, unspecified	0.059	0.017	3.63	2.20–5.98
	J45.9 Asthma, unspecified	0.159	0.08	2.18	1.58–3.00
	Z86.4 Personal history of psychoactive substance abuse	0.166	0.09	2	1.46–2.73
	D64.9 Anemia, unspecified	0.076	0.035	2.28	1.47–3.54
	R11 Nausea and vomiting	0.079	0.037	2.22	1.44–3.42
	I10 Essential (primary) hypertension	0.321	0.233	1.56	1.22–2.00
	Z72.0 Tobacco use	0.055	0.023	2.46	1.48–4.10
	Z87.1 Personal history of diseases of the digestive system	0.09	0.047	2.01	1.34–3.02
	J44.9 Chronic obstructive pulmonary disease, unspecified	0.052	0.022	2.45	1.45–4.15
	G56.0 Carpal tunnel syndrome	0.062	0.03	2.15	1.32–3.49
	E78.0 Pure hypercholesterolemia	0.152	0.097	1.66	1.20–2.29
	F17.1 Harmful use	0.062	0.03	2.13	1.32–3.44
	Z88.0 Personal history of allergy to penicillin	0.093	0.052	1.87	1.26–2.78
	K52.9 Non-infective gastro-enteritis and colitis, unspecified	0.076	0.041	1.91	1.23–2.97
	N39.0 Urinary tract infection, site not specified	0.072	0.04	1.9	1.21–2.97
	E66.9 Obesity, unspecified	0.069	0.038	1.9	1.20–3.00
	I20.9 Angina pectoris, unspecified	0.076	0.043	1.84	1.18–2.87
	R69 Unknown and unspecified causes of morbidity	0.083	0.048	1.79	1.17–2.73
	K62.5 Hemorrhage of anus and rectum	0.059	0.033	1.82	1.11–2.99
	K59.0 Constipation	0.059	0.034	1.75	1.07–2.87
	I25.9 Chronic ischemic heart disease, unspecified	0.055	0.032	1.76	1.06–2.92
	K21.0 Gastro-esophageal reflux disease with esophagitis	0.052	0.03	1.77	1.04–3.00
	R19.4 Change in bowel habit	0.062	0.038	1.66	1.02–2.69
OPCS-4	G45.9 Unspecified diagnostic fiberoptic endoscopic examination of upper gastrointestinal tract	0.155	0.088	1.89	1.37–2.60
	A65.1 Carpal tunnel release	0.062	0.029	2.2	1.38–3.52
	Z92.6 Abdomen NEC	0.062	0.035	1.82	1.13–2.93
	J18.3 Total cholecystectomy NEC	0.066	0.039	1.72	1.08–2.75
	Z28.2 Caecum	0.114	0.078	1.52	1.05–2.19
	Z27.4 Duodenum	0.141	0.102	1.45	1.04–2.02

Abbreviations: International Classification of Disease, 10th revision (ICD-10); Office of Population Censuses and Surveys Classification of Interventions and Procedures, 4th revision (OPCS-4); Odds ratio (OR); Confidence interval (CI); Not Elsewhere Classified (NEC).