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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2021 Dec 22;86(Pt 3):816–826. doi: 10.1016/j.semcancer.2021.12.006

Figure 3. Mutations in intermediate filament proteins result in mitotic defects in cell division.

Figure 3.

A) Preventing phosphorylation through alanine mutations results in intermediate filaments that are unable to be disassembled during mitosis and cytokinesis. These filaments form an intermediate filament (IF) bridge between the daughter cells that can result in polyploidy. B) Phosphomimetic mutations or hyperphosphorylation of the intermediate filaments alters mitotic dynamics through tubulin localization and also leads to polyploidy.