Table 3: Characteristics of infants with intracranial hemorrhage compared to those without.
ICH: intracranial hemorrhage; IQR: interquartile range; kg: kilograms; ECLS: extracorporeal life support; CPR: cardiopulmonary resuscitation; PaO2: arterial partial pressure of oxygen; INR: international normalized ratio; PTT: partial thromboplastin time; NICU: neonatal intensive care unit; PICU: pediatric intensive care unit; OR: operating room; MRI: magnetic resonance imaging.
| Variable | ICH n = 16 |
No ICH n = 58 |
p-value |
|---|---|---|---|
| Age, days: median (IQR) | 2 (1.5–5) | 6 (1–54) | 0.07 |
| Age ≤ 28 days old: n (%) | 15 (93.8) | 39 (67.2) | 0.05 |
| Gestational age, weeks: median (IQR) | 37.6 (35.4–40.2) | 38.6 (37.0–39.4) | 0.68 |
| Birth weight, kg: median (IQR) | 2.8 (2.4–3.5) | 3.0 (2.5–3.5) | 0.73 |
| Weight at ECLS cannulation, kg: median (IQR) | 3.3 (2.7–3.6) | 3.5 (2.9–4.3) | 0.06 |
| Sex, % female: n (%) | 8 (50.0) | 23 (39.7) | 0.60 |
| ECLS Indication: n (%) | |||
| ECLS within 6 hours of cardiac surgery: n (%) | 6 (37.5) | 18 (31.0) | 0.76 |
| Pre-ECLS CPR: n (%) | 6 (37.5) | 14 (24.1) | 0.34 |
| Pre-ECLS vasopressors: n (%) | 16 (100) | 51 (87.9) | 0.34 |
| Pre-ECLS pH: median (IQR) | 7.20 (7.09–7.34) | 7.22 (7.09–7.35) | 0.89 |
| Pre-ECLS base deficit, median (IQR) | −7 (−12.2 to −4) | −5 (−11 to 1) | 0.36 |
| Pre-ECLS PaO2, mmHg: median (IQR) | 48 (30–103) | 43 (31–53) | 0.67 |
| Pre-ECLS hemoglobin, g/dL: median (IQR) | 14.4 (12.8–16.6) | 13.7 (12.2–15.1) | 0.22 |
| Pre-ECLS platelet count, ×103: median (IQR) | 148 (106–193) | 219 (161–297) | 0.004 |
| Pre-ECLS INR: median (IQR) | 1.61 (1.4–2.3) | 1.39 (1.2–1.5) | 0.017 |
| Pre-ECLS PTT: median (IQR) | 52.4 (46.5–112.6) | 53.2 (40.2–65.4) | 0.19 |
| Pre-ECLS fibrinogen, mg/dL: median (IQR) | 153 (109–233) | 177 (159–231) | 0.32 |
| ECLS type: n (%) | 0.67 | ||
| ECLS cannulation location: n (%) | 0.52 |