Table 3.
Summary of published associations between telomere length and commonly used epigenetic age clocks or age acceleration measures
| Author (year) | Study population | N | Age | TL assay | Epigenetic age | Associations |
|---|---|---|---|---|---|---|
| Marioni et al. (2016) [19] |
LBC1921 LBC1936 |
920 | 70 + | qPCR | DNAmAge | Weak to no association |
| Chen et al. (2017) [18] |
WHI FHS BHS |
804 909 826 |
60–70 61–74 40–47 |
TRF | IEAA1 | No association |
| IEAA2 | Weak to no association | |||||
| EEAA3 | No association | |||||
| EEAA4 |
Negative association (WHI, FHS) No association (BHS) |
|||||
| Belsky et al. (2018) [15] | Dunedin | 1037 | 38 | qPCR | DNAmAge | No association |
| Hannum | No association |
1IEAA measured using CPGs from the Hannum epigenetic clock
2IEAA measured using CPGs from Horvarth DNAmAge epigenetic clock
3EEAA measured using CPGs from Hannum epigenetic clock, adjusted for the proportion naive CD8 + T cells, memory CD8 + cells, and plasmablasts
4EEAA measured using CPGs from Horvath DNAmAge epigenetic clock