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. 2022 May 18;44(3):1861–1869. doi: 10.1007/s11357-022-00586-4

Table 3.

Summary of published associations between telomere length and commonly used epigenetic age clocks or age acceleration measures

Author (year) Study population N Age TL assay Epigenetic age Associations
Marioni et al. (2016) [19]

LBC1921

LBC1936

920 70 +  qPCR DNAmAge Weak to no association
Chen et al. (2017) [18]

WHI

FHS

BHS

804

909

826

60–70

61–74

40–47

TRF IEAA1 No association
IEAA2 Weak to no association
EEAA3 No association
EEAA4

Negative association (WHI, FHS)

No association (BHS)

Belsky et al. (2018) [15] Dunedin 1037 38 qPCR DNAmAge No association
Hannum No association

1IEAA measured using CPGs from the Hannum epigenetic clock

2IEAA measured using CPGs from Horvarth DNAmAge epigenetic clock

3EEAA measured using CPGs from Hannum epigenetic clock, adjusted for the proportion naive CD8 + T cells, memory CD8 + cells, and plasmablasts

4EEAA measured using CPGs from Horvath DNAmAge epigenetic clock