Table 2.

AIBL cross-sectional hippocampal volume

Population (n)	Predictor	Estimate	SE	CI 95	P predictor
Whole cohort (329)	Zhang EN	− 0.021	0.013	− 0.047 – 0.005	0.149
	Zhang BLUP	− 0.009	0.013	− 0.034 – 0.016	0.471
	Hannum	− 0.029	0.009	− 0.047 – − 0.11	0.007
	Horvath	− 0.012	0.008	− 0.027 – 0.003	0.149
	Phenoage	− 0.019	0.006	− 0.031 – − 0.006	0.009**
Aβ + (145)	Zhang EN	− 0.050	0.021	− 0.092 – − 0.008	0.032**
	Zhang BLUP	− 0.030	0.020	− 0.070 – 0.010	0.136
	Hannum	− 0.045	0.014	− 0.072 – −  − 0.018	0.003**
	Horvath	− 0.020	0.011	− 0.041 – 0.002	0.097
	Phenoage	− 0.034	0.010	− 0.054 – − 0.015	0.003**
Aβ − (184)	Zhang EN	0.002	0.015	− 0.028 – 0.032	0.875
	Zhang BLUP	0.014	0.015	− 0.016 – 0.044	0.875
	Hannum	− 0.009	0.011	− 0.031 – 0.014	0.875
	Horvath	0.002	0.010	− 0.017 – 0.022	0.875
	Phenoage	0.002	0.008	− 0.014 – 0.017	0.875
Cognitively unimpaired (220)	Zhang EN	− 0.014	0.014	− 0.041 – 0.013	0.507
	Zhang BLUP	− 0.001	0.014	− 0.028 – 0.025	0.921
	Hannum	− 0.024	0.010	− 0.044 – − 0.004	0.099
	Horvath	− 0.001	0.009	− 0.019 – 0.016	0.921
	Phenoage	− 0.010	0.007	− 0.024 – 0.004	0.414
Cognitively unimpaired Aβ + (65)	Zhang EN	− 0.069	0.025	− 0.120 – − 0.019	0.019**
	Zhang BLUP	− 0.034	0.024	− 0.082 – 0.015	0.209
	Hannum	− 0.058	0.019	− 0.096 – − 0.020	0.018**
	Horvath	− 0.013	0.018	− 0.049 – 0.023	0.483
	Phenoage	− 0.038	0.016	− 0.069 – − 0.007	0.030**
Cognitively unimpaired Aβ − (155)	Zhang EN	0.004	0.016	− 0.029 – 0.036	0.828
	Zhang BLUP	0.014	0.017	− 0.019 – 0.047	0.828
	Hannum	− 0.015	0.012	− 0.039 – 0.010	0.828
	Horvath	0.004	0.011	− 0.017 – 0.026	0.828
	Phenoage	− 0.004	0.008	− 0.020 – 0.012	0.828

AIBL cross-sectional results for associations between accelerated ageing (DBAge) and hippocampal volume. p values shown represent values after FDR correction. Bolded values with ** represent values that remain significant after FDR correction

SE standard error, CI 95 95% confidence intervals, P predictor p value of clock used, EN elastic net BLUP best linear unbiased prediction, Aβ Amyloid-β