Table 3.

ADNI cross-sectional hippocampal volume

Population (n)	Predictor	Estimate	SE	CI 95	P predictor
Whole cohort (382)	Zhang EN	− 0.004	0.006	− 0.016 – 0.007	0.482
	Zhang BLUP	− 0.004	0.006	− 0.015 – 0.007	0.445
	Hannum	− 0.002	0.004	− 0.011 – 0.006	0.602
	Horvath	− 0.003	0.004	− 0.010 – 0.004	0.425
	Phenoage	− 0.003	0.003	− 0.010 – 0.003	0.344
Aβ + (194)	Zhang EN	− 0.007	0.009	− 0.025 – 0.010	0.392
	Zhang BLUP	− 0.006	0.008	− 0.022 – 0.010	0.428
	Hannum	− 0.005	0.006	− 0.017 – 0.006	0.371
	Horvath	− 0.006	0.005	− 0.016 – 0.003	0.193
	Phenoage	− 0.007	0.005	− 0.016 – 0.002	0.146
Aβ − (188)	Zhang EN	− 0.001	0.008	− 0.017 – 0.015	0.866
	Zhang BLUP	− 0.001	0.008	− 0.016 – 0.014	0.862
	Hannum	0.005	0.006	− 0.008 – 0.017	0.471
	Horvath	0.000	0.005	− 0.010 – 0.011	0.955
	Phenoage	0.002	0.005	− 0.008 – 0.011	0.727
Cognitively unimpaired (117)	Zhang EN	− 0.004	0.008	− 0.019 – 0.011	0.568
	Zhang BLUP	− 0.008	0.007	− 0.021 – 0.006	0.264
	Hannum	− 0.013	0.006	− 0.025 – 0.000	0.043
	Horvath	0.000	0.005	− 0.009 – 0.010	0.920
	Phenoage	− 0.002	0.004	− 0.011 – 0.007	0.662
Cognitively unimpaired Aβ + (34)	Zhang EN	− 0.033	0.020	− 0.074 – 0.008	0.111
	Zhang BLUP	− 0.031	0.016	− 0.064 – 0.002	0.061
	Hannum	− 0.029	0.014	− 0.057 – − 0.001	0.046**
	Horvath	0.005	0.011	− 0.018 – 0.029	0.647
	Phenoage	− 0.013	0.011	− 0.036 – 0.011	0.268
Cognitively unimpaired Aβ − (83)	Zhang EN	− 0.002	0.009	− 0.019 – 0.016	0.825
	Zhang BLUP	− 0.002	0.008	− 0.018 – 0.013	0.770
	Hannum	− 0.011	0.008	− 0.027 – 0.004	0.143
	Horvath	− 0.004	0.006	− 0.015 – 0.008	0.544
	Phenoage	− 0.001	0.005	− 0.012 – 0.009	0.802

ADNI cross-sectional validation results for associations between accelerated ageing (DBAge) hippocampal volume. p values shown represent values before FDR correction. Bolded values with ** represent values that appeared significant

SE standard error, CI 95 95% confidence intervals, P predictor p value of clock used, EN elastic net, BLUP best linear unbiased prediction, Aβ Amyloid-β